The third generation pill controversy ("continued")

End of the line for "third-generation-pill" controversy?

Through modification of an in vitro test for thrombosis formation, a Dutch research group has made three significant findings: 1) third-generation oral contraceptives (OCs) induce a resistance to the blood's natural anticoagulation system of a magnitude close to that induced by a mutation in coagulation factor V Leiden; 2) second-generation OCs show only part of the effect; and 3) in OC users h...

The pill. The controversy continues.

Oral contraceptives (OC) are, or perhaps more correctly, were, until recently, being taken by approximately 6.5 million women worldwide, which corresponds to approximately 6% of all women of reproductive age. OCs have been available since the early 1960s and there is substantial evidence to suggest that no single medication has had such a profound impact on our reproduction and social life as t...

Thermoregulation in Dinosaurs: A Continued Controversy

The Continued Development of the Third-generation Shallow Water Wave Model "SWAN"

The main objective is to support and assist the development, validation and verification of the SWAN model and its use in operational conditions. The development is based on new scientific insights in the evolution of waves in shallow water. The verification and validation is based on field observations and laboratory experiments supplemented with numerical experiments. Operational use is suppo...

Third-generation oral contraceptive and deep venous thrombosis: from epidemiologic controversy to new insight in coagulation.

Four epidemiologic studies showed a twofold increase in risk of deep venous thrombosis with the use of oral contraceptives containing third-generation progestins, relative to second-generation products. These findings have been strongly debated ever since, and new studies have been added. In the current article we examine whether the findings can be explained by potential biases or other shortc...